Table 3. Absolute and Relative Rates of Main Outcomes Stratified by Index ICH Hematoma Location Within Strata of Patients With or Without Atrial Fibrillation or Previous Occlusive Vascular Disease.
| Event during follow-up | Atrial fibrillationa,b | Previous occlusive vascular diseasea,b,c | ||||||
|---|---|---|---|---|---|---|---|---|
| Yes | No | Yes | No | |||||
| Lobar (n = 216) | Nonlobar (n = 273) | Lobar (n = 218) | Nonlobar (n = 294) | Lobar (n = 218) | Nonlobar (n = 294) | Lobar (n = 816) | Nonlobar (N = 961) | |
| Recurrent ICH | ||||||||
| No. of events/person-years | 6/345 | 5/376 | 74/1792 | 30/2442 | 17/267 | 6/571 | 63/1871 | 29/2248 |
| Absolute event rate per 100 person-years (95% CI) | 1.74 (0.78-3.87) | 1.33 (0.55-3.19) | 4.13 (3.29-5.19) | 1.23 (0.86-1.76) | 6.38 (3.96-10.26) | 1.05 (0.47-2.34) | 3.37 (2.63-4.31) | 1.29 (0.90-1.86) |
| Relative rate, aHR (95% CI)d | 1.13 (0.49-2.63) | 1 [Reference] | 2.91 (2.15-3.95) | 1 [Reference] | 6.15 (2.98-12.67) | 1 [Reference] | 2.20 (1.61-3.01) | 1 [Reference] |
| Ischemic stroke | ||||||||
| No. of events/person-years | 6/345 | 13/376 | 25/1792 | 37/2442 | 8/267 | 13/571 | 23/1871 | 37/2248 |
| Absolute event rate per 100 person-years (95% CI) | 1.74 (0.78-3.87) | 3.45 (2.01-5.95) | 1.40 (0.94-2.06) | 1.51 (1.10-2.09) | 3.00 (1.50-6.00) | 2.28 (1.32-3.92) | 1.23 (0.82-1.85) | 1.65 (1.19-2.27) |
| Relative rate, aHR (95% CI)d | 0.50 (0.26-0.97) | 1 [Reference] | 0.92 (0.65-1.30) | 1 [Reference] | 1.42 (0.77-2.61) | 1 [Reference] | 0.72 (0.50-1.02) | 1 [Reference] |
| Myocardial infarction | ||||||||
| No. of events/person-yearse | NR | NR | NR | NR | NR | NR | NR | NR |
| Absolute event rate per 100 person-years (95% CI) | 0.87 (0.28-2.70) | 1.33 (0.55-3.19) | 0.33 (0.15-0.75) | 0.53 (0.31 0.92) | 0.75 (0.19-3.00) | 1.05 (0.47-2.34) | 0.37 (0.18-0.78) | 0.53 (0.30-0.94) |
| Relative rate, aHR (95% CI)d | NEf | 1 [Reference] | 0.62 (0.31-1.21) | 1 [Reference] | 0.59 (0.20-1.75) | 1 [Reference] | 0.72 (0.38-1.39) | 1 [Reference] |
| MACEsg | ||||||||
| No. of events/person-years | 38/319 | 62/367 | 184/1728 | 158/2413 | 48/241 | 57/569 | 174/1806 | 163/2211 |
| Absolute event rate per 100 person-years (95% CI) | 11.91 (8.66-16.36) | 16.90 (13.18-21.68) | 10.65 (9.21-12.30) | 6.55 (5.60-7.65) | 19.90 (14.99-26.40) | 10.01 (7.72-12.98) | 9.63 (8.30-11.18) | 7.37 (6.32-8.60) |
| Relative rate, aHR (95% CI)d | 0.75 (0.57-0.99) | 1 [Reference] | 1.45 (1.25-1.69) | 1 [Reference] | 1.57 (1.20-2.07) | 1 [Reference] | 1.21 (1.04-1.40) | 1 [Reference] |
Abbreviations: aHR, adjusted hazard ratio; ICH, intracerebral hemorrhage; MACE, major adverse cardiovascular event; NE, not estimated; NR, not reported.
Classified based on information at baseline.
Location of hematoma on brain scan of first-ever intracerebral hemorrhage.
Medical history of ischemic stroke, myocardial infarction, or peripheral arterial disease at baseline.
Hazard ratio adjusted for sex, age (<75 [reference], 75-84, or ≥85 years), hypertension, atrial fibrillation, previous ischemic stroke, myocardial infarction, peripheral arterial disease, diabetes, chronic obstructive pulmonary disease (as a marker of smoking), diagnoses indicative of high alcohol use, and use of medications (separate covariates for each of the following drug classes: platelet antiaggregant [low-dose aspirin or clopidogrel], anticoagulants [direct oral anticoagulants or vitamin K antagonist], antihypertensives, and statins).
Not reported to preserve anonymity in view of small cell counts.
Not estimated because of sparse events.
Major adverse cardiovascular event defined as stroke (ICH or ischemic stroke), myocardial infarction, systemic embolism, or vascular death.