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. 2023 Mar 8;8(5):e154940. doi: 10.1172/jci.insight.154940

Figure 1. Adipose SWELL1 supports adipose tissue expansion and maintenance.

Figure 1

(A) Total body weight of WT (n = 10) and Adipo KO (n = 8) mice (males) fed with high-fat/high-sucrose (HFHS) diet for 27 weeks. (B) Body composition for total fat and lean mass estimated by NMR from mice in A at 21-week time point of HFHS diet. (C) Representative images of epididymal (eWAT) and inguinal (iWAT) fat pads isolated from mice in A. (D) Total fat pad weights and ratio of fat pad over body weight of WT and Adipo-KO mice from A. (E) Total body weight of WT (n = 8) and Adipo-KO (n = 9) mice (males) fed with Gubra Amylin NASH (GAN) diet for 23–25 weeks. (F) Body composition for total fat and lean mass estimated by EchoMRI from mice in E at 22-week time point of GAN diet. (G) Total fat pad weights and ratio of fat pad over body weight of WT and Adipo-KO mice from E. Data are represented as mean ± SEM. Two-tailed unpaired t test was used in A, B, and D–G where *, **, and *** represent P < 0.05, P < 0.01, and P < 0.001, respectively.