Table 4.
Simulated steady-state Cabotegravir Trough (Ctrough)1 for extremes of BMI:
CAB Ctrough (ug/mL, Median [90% prediction interval]) for BMI 16.5 kg/m2 (Body weight 43.0kg F; 50.6kg M) | CAB Ctrough (ug/mL, Median [90% prediction interval]) for BMI 50 kg/m2 (Body weight 130.6kg F; 153.9kg M) | |
---|---|---|
Male | 2.707 [0.931, 5.648] ug/mL | 1.102 [0.339, 2.355] ug/mL |
Female | 3.275 [1.291, 6.676] ug/mL | 1.368 [0.527, 2.828] ug/mL |
For reference: CAB PA-IC90: 0.166 μg/mL; 4*PA-IC90: 0.664 μg/mL; 8*PA-IC90: 1.33 μg/mL