Table 7.

Comparison of CSF metabolites between male and female patients using 1:1 propensity-matched comparison by matching with age, body mass index (BMI), hypertension, and serum creatinine

Metabolites in CSF	LC–MS signal integration (mean ± SD) (× 103 a.u.)		fold change	p value #
	Male	Female	Male/Female	male vs. female
Increased metabolite levels in male patients compared to female patients
Xylulose 5-P	99.91 ± 19.54	86.14 ± 12.08	1.159	0.022*
Decreased metabolite levels in male patients compared to female patients
Uric acid	470.37 ± 181.03	475.69 ± 235.73	0.988	0.943
cysteine	31.94 ± 6.52	32.98 ± 7.06	0.968	0.661
uridine	5252.33 ± 784.14	5958.56 ± 1208.74	0.881	0.059
serine	179.38 ± 48.81	211.11 ± 50.56	0.849	0.081
5-hydroxyindoleacetic acid	95.72 ± 34.07	126.29 ± 42.50	0.758	0.032*
Hypoxanthine	61.45 ± 14.11	85.24 ± 15.41	0.721	0.001*
Taurine	7.95 ± 3.58	13.18 ± 5.91	0.603	0.005*

^#p value was calculated using two sample t test

^*p < 0.05