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. 2022 Nov 17;89(1):e13647. doi: 10.1111/aji.13647

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© 2022 The Authors. American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Experiments showing size, morphology and purity of the exosome isolation from serum samples of high‐grade serous ovarian cancer patients. Nanoparticle tracking analysis using ZetaView, illustrating: (A) size distribution of representative samples; (B) median exosome size and concentration and; (C) negative contrast staining and transmission electron microscopy showing exosome morphology and immune electron microscopy of the tetraspanins CD63 and CD81, and the ovarian cancer marker CA‐125. Stars (*p ≤ .05, **p < .01) indicate a significant difference (p = .009) in the postoperative exosome concentration between Group 1 and Group 2.