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. 2022 Nov 9;29(1):e3457. doi: 10.1002/psc.3457

FIGURE 8.

FIGURE 8

(A) Crystal structure of gp41 helix bundle (pdb: 1szt) with C‐terminal heptad repeat (CHR, blue) and N‐terminal heptad repeat (NHR, beige). 76 (B) Sequence of C34 and derived inhibitors with modifications. SC35E(SBn) 5 H 9 and SC22E(SBn) 5 H 9 have been altered introducing additional salt bridges to stabilize helicity and solubility. The bold histidine residue has been introduced to increase NHR K574 reactivity. C corresponds to a C‐terminally attached cholesterol. (C) Chemical structure of the employed modifiers and their reactivity.