FIGURE 1.

Proposed conceptual framework. Dysregulations of hormonal appetite signaling are observed in obesity, which can foster uncontrolled eating, especially of highly palatable foods. HPA‐axis hyperactivity, for example, due to chronic stress or medication, can also dysregulate the highly sensitive system of appetite regulation, thereby fueling an orexigenic hormonal profile, but also detrimental metabolic processes and mood impairments. These disturbances can, in turn, promote further weight gain along with HPA‐axis alterations and result in a vicious circle. Orexigenic, anorexigenic