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. Author manuscript; available in PMC: 2023 Apr 6.
Published in final edited form as: Nat Aging. 2022 May 16;2(6):484–493. doi: 10.1038/s43587-022-00220-0

Extended Data Fig. 2 |. effects of various inducers of cellular senescence on epigenetic aging.

Extended Data Fig. 2 |

Measurement of EpiAge with four epigenetic clocks on primary human fibroblasts isolated from neonatal foreskins of 14 donors. Fibroblasts were cultured until replicative senescence (red), induced to senesce by X-irradiation (green), induced to senesce by ectopic expression of activated ras oncogene (orange) or untreated (blue). Methylation profiles of these cells were analyzed using the (a) Skin&blood clock, (b) Horvath clock, (c) Hannum clock and (d) PhenoAge clock.