FIGURE 1.

Study design. The study comprised a total of 32 mice, divided into five groups. The first group of eight mice (group 1 at the top), underwent four longitudinal dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) sessions, at 4, 8, 12, and 16 weeks, after initiation of a high‐fat diet. Groups 2–5 were instead used for comparison between DCE‐MRI and histology. Each group consisted of six mice, which underwent imaging and euthanasia respectively at 4, 8, 12, and 16 weeks after high‐fat diet initiation. Green circles indicate DCE‐MRI–only sessions for group 1. Green and yellow circles indicate DCE‐MRI and euthanasia sessions for groups 2–5. The gray dashed arrows indicate maintenance of a high‐fat diet