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. 2023 Apr 5;45(1):2197075. doi: 10.1080/0886022X.2023.2197075

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 8. — Effects of PA and PA + HG on MAPK pathway in the HMCs and the regulatory role of Rg1 in the T2DM mice. (A) The bands of p-JNK, JNK, p-P38, P38, p-ERK, ERK, and GAPDH in the HMCs (Western blotting, n = 3). (B) The relative expression of p-ERK/ERK in the HMCs over control. (C) The relative expression of p-JNK/JNK in the HMCs over control. (D) The relative expression of p-P38/P38 in the HMCs over control. (E) The bands of p-JNK, JNK, p-P38, P38, p-ERK, ERK, and β-actin in the mice (Western blotting, n = 4). (F) The relative expression of p-ERK/ERK over control. (G) The relative expression of p-JNK/JNK over control. (H) The relative expression of p-P38/P38 over control. The data are expressed as the mean ± SD, *p< 0.05, **p< 0.01 compared with the control group; ^#p< 0.05, ^##p< 0.01 compared with the HFD + STZ group.