Figure 4.

Correlation of the estimated circadian rhythm of the hepatic Bmal1 and miR‐27b‐3 expression of CD A), CJL B), and TJL C) analyzed by Cosinor method. Control day group (CD group): animals housed at 12 h light/dark cycle, administered water (ZT0) and sacrificed at ZT0, 0.5, 1, 3, 6, 12, 13, 15, 18, and 24 h; Control jet lag group (CJL group): animals housed at 12 h light/dark cycle, administered water at ZT6 and immediately moved to dark and sacrificed at ZT6, 7, 9, and 12. Treatment jet lag group (TJL group): animals housed at 12 h light/dark cycle, administered GSPE (250 mg kg⁻¹ bw) at ZT6 and immediately moved to dark and sacrificed at ZT6, 7, 9, and 12.