. 2022 Sep 7;53(1):e13862. doi: 10.1111/eci.13862

TABLE 2.

Meta‐analysis of risk factors for cardiac implantable electronic devices malfunctions associated with radiation therapy

	Studies (n)	Patients (n)	Malfunctions (n)	Risk ratio (95% CI)	p	I ²% (95% CI)	Egger's test p
Neutron‐producing vs. non‐neutron‐producing energy	13	1350	65	9.98 (5.09–19.60)	<.0001	4 (0–61.7)	.472
PM/ CRT‐P vs. ICD/ CRT‐D	25	3018	123	2.07 (1.40–3.06)	.0003	1 (0–49.4)	.074
Dmax ≤2Gy vs. Dmax >2Gy	8	718	17	0.93 (0.31–2.76)	.8983	0 (0–84.7)	.282

Studies (n)

Patients (n)

Malfunctions (n)

Risk ratio (95% CI)

I ²% (95% CI)

Egger's test

Neutron‐producing vs. non‐neutron‐producing energy

1350

9.98 (5.09–19.60)

<.0001

4 (0–61.7)

.472

PM/ CRT‐P vs. ICD/ CRT‐D

3018

123

2.07 (1.40–3.06)

.0003

1 (0–49.4)

.074

Dmax ≤2Gy vs. Dmax >2Gy

718

0.93 (0.31–2.76)

.8983

0 (0–84.7)

.282

Abbreviations: CRT‐D, cardiac resynchronization therapy and defibrillator; CRT‐P, cardiac resynchronization therapy and pacing; Dmax, maximal radiation dose at device; Gy, grey; ICD, implantable cardioverter defibrillator; PM, pacemakers.