FIGURE 2.

Integrative model of diabetes. (A) Subjects are deeply characterized regarding aetiological factors (including genes, lifestyle and environmental factors), underlying physiopathological mechanisms and metabolic and haemodynamic factors that they are exposed to. They are placed correspondingly onto the aetiology, mechanisms and milieu plan. The location of a subject in each plan can be predicted by knowing their position in the others. Ultimately, aetiology, mechanisms and milieu project the subject onto the metabolic phenotype plan where its health condition is assessed also considering diabetes complications as nephropathy, retinopathy and cardiovascular complications. Each subject path through time in the metabolic phenotype plan can be analysed but also predicted, leveraging therapeutic and preventive strategies. (B) Aetiology, mechanisms and milieu for each subject can be summarized and more easily visible on a radarplot.