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. 2022 Jun 16;14(1):e1741. doi: 10.1002/wrna.1741

FIGURE 2.

FIGURE 2

Schematic of eIF2‐dependent stress granule induction. (a) Phosphorylation of eIF2α (p‐eIF2α), mediated by an eIF2α kinase. (b) Translation initiation is inhibited (stalled) following the recruitment of p‐eIF2α to the translation initiation complex. (c) Formation of a stress granule following the aggregation of stalled initiation complexes in combination with SG regulatory proteins including G3BP1, TIA‐1, and CAPRIN‐1. (d) SG disassembly occurs rapidly upon resolution of stress and translation can resume. SG contain translationally silent mRNA, 40S ribosomal subunits, eukaryotic initiation factors (e.g., eIF4G, eIF4A, and eIF3), and RNA binding proteins [e.g., G3BP1, cell cycle‐associated protein 1 (CAPRIN1), human antigen R (HuR), ubiquitin‐specific peptidase 10 (USP10), UBAP2L, and T‐cell intracellular antigen 1 (TIA1)]. Figure made using Biorender.