TABLE 1.

Eligibility criteria

Randomized controlled trials

Patients ≥16 years diagnosed with non‐erosive reflux disease a

Compared proton pump inhibitors, histamine‐2‐receptor antagonist, potassium‐competitive acid blockers, or alginates with each other, or with placebo

Minimum duration of therapy of 2 weeks

Assessment of failure of complete relief of gastro‐esophageal reflux symptoms (heartburn and/or regurgitation) or adequate relief of gastro‐esophageal reflux symptoms at last time point of assessment in the trial

^a Defined as the presence of heartburn and/or regurgitation and normal upper endoscopy, with or without positive pH monitoring and impedance testing of ≥24 hours of duration, performed off anti‐reflux medications.