TABLE 3.

Association of plasma HDL‐C, triglyceride, LDL‐C, and glucose measured at each longitudinal exam with incident AD adjusted for age and sex

		HDL‐C						Triglyceride b
Exam	No. events a	N	Beta	HR c	Lower 95% CL	Upper 95% CL	P‐Value	N	beta	HR c	Lower 95% CL	Upper 95% CL	P‐value
1	236	4200	−0.14	0.87	0.76	1.00	0.045	4213	0.29	1.34	1.12	1.59	0.0010
2	217	3630	−0.18	0.83	0.72	0.97	0.016	3630	0.24	1.27	1.10	1.47	0.0014
3	208	3449	−0.06	0.95	0.83	1.08	0.40	3461	0.15	1.16	0.97	1.39	0.16
4	217	3605	−0.10	0.91	0.80	1.03	0.14	3620	0.11	1.12	0.95	1.31	0.18
5	208	3479	−0.08	0.92	0.81	1.05	0.21	3490	0.18	1.19	1.23	1.39	0.024
6	186	3261	−0.20	0.82	0.72	0.93	0.0021	3269	0.18	1.20	1.03	1.40	0.022
7	156	3106	−0.24	0.79	0.68	0.92	0.0024	3112	0.28	1.33	1.10	1.59	0.0027
8	85	2739	−0.01	1.01	0.81	1.26	0.90	2740	0.16	1.18	0.85	1.63	0.32
9	14	2148	−0.09	0.91	0.55	1.50	0.71	2149	0.28	1.32	0.65	2.66	0.44

		Diastolic blood pressure						Glucose
Exam	Number events a	N	beta	HR d	Lower 95% CL	Upper 95% CL	p‐Value	N	beta	HR c	Lower 95% CL	Upper 95% CL	p‐Value
1	236	4279	0.05	1.05	0.93	1.19	0.44	4113	0.12	1.12	1.01	1.26	0.041
2	217	3712	−0.02	0.98	0.87	1.10	0.70	3561	0.11	1.12	1.04	1.20	0.0020
3	208	3577	0.07	1.07	0.94	1.22	0.29	3364	0.08	1.09	1.01	1.16	0.022
4	217	3707	0.10	1.10	0.97	1.26	0.15	3468	0.10	1.11	1.05	1.17	0.00040
5	208	3512	−0.007	0.99	0.84	1.18	0.94	3449	0.06	1.07	1.01	1.13	0.020
6	186	3299	0.04	1.04	0.91	1.20	0.54	3216	0.08	1.09	1.03	1.15	0.0041
7	162	3255	0.002	1.00	0.83	1.21	0.98	3065	0.12	1.13	1.05	1.12	0.00060
8	85	2818	−0.12	0.89	0.71	1.11	0.29	2688	0.14	1.14	1.04	1.26	0.0058
9	14	2253	−0.08	0.92	0.55	1.53	0.75	2105	0.33	1.39	1.06	1.82	0.017

^a Maximum number incident AD cases shown among subjects with for diastolic blood pressure measurements; numbers may be slightly less for other factors (see Table S3).

^b Log2 transformed values for betas and HRs.

^c Hazard ratio (HR) and 95% confidence interval for each 15 mg/dL increase.

^d Hazard ratio (HR) and 95% confidence interval for each 10 mm increase.