TABLE 4.
Association of blood lipids and glucose with incident AD by age group adjusted for age and sex
| Group (age range in years) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Early adulthood) (35–50) | Middle adulthood (51–60) | Late adulthood (61–70) | |||||||||||||||||||
| Risk factor | N | N events | Beta | HR a | Lower 95% CL | Upper 95% CL | P‐value | N | N events | Beta | HR a | Lower 95% CL | Upper 95% CL | P‐value | N | N events | Beta | HR a | Lower 95% CL | Upper 95% CL | P‐value |
| HDL‐C | 2875 | 156 | −0.17 | 0.85 | 0.72 | 0.99 | 0.041 | 1803 | 163 | −0.20 | 0.82 | 0.70 | 0.96 | 0.014 | 1463 | 176 | −0.12 | 0.89 | 0.77 | 1.02 | 0.11 |
| TG b | 2879 | 157 | 0.28 | 1.33 | 1.02 | 1.57 | 0.0013 | 1809 | 163 | 0.11 | 1.12 | 0.93 | 1.35 | 0.22 | 1470 | 176 | 0.05 | 1.05 | 0.89 | 1.23 | 0.57 |
| BG | 2820 | 154 | 0.07 | 1.07 | 0.92 | 1.25 | 0.39 | 1792 | 163 | 0.14 | 1.15 | 1.06 | 1.23 | 0.00029 | 1427 | 171 | 0.06 | 1.07 | 1.00 | 1.14 | 0.056 |
| DBP | 2931 | 163 | 0.05 | 1.05 | 0.91 | 1.20 | 0.53 | 1863 | 170 | −0.05 | 0.95 | 0.83 | 1.09 | 0.48 | 1501 | 181 | 0.13 | 1.14 | 1.01 | 1.29 | 0.041 |
Abbreviations: HDL‐C, high‐density lipoprotein cholesterol; TG, triglyceride; BG, blood glucose; DPB, diastolic blood pressure.
aHazard ratio (HR) and 95% confidence interval for a 15 mg/dL increase of HDL‐C and BG, and a 10 mm increase in DBP.
b
Log2 transformed values for betas and HRs.