TABLE 3.

Odds ratios (ORs) and 95% confidence intervals (CIs) for the relationship between pulmonary function (PF) and brain pathologies in the autopsy participants (n = 540)

		Categorical PF (quartiles) a
Brain pathologies	Continuous PF	Middle vs Highest	Lowest vs Highest
	OR (95% CI)	OR (95% CI)	OR (95% CI)
AD pathologies
Global AD pathology	0.92 (0.86‐0.98)	1.26 (1.15‐1.39)	1.32 (1.19‐1.47)
Aβ load	0.92 (0.87‐0.99)	1.24 (1.13‐1.37)	1.32 (1.18‐1.46)
Neurofibrillary tangles	0.93 (0.87‐0.99)	1.13 (1.01‐1.26)	1.16 (1.01‐1.31)
Chronic infarcts
Gross infarcts	0.89 (0.67‐1.19)	0.98 (0.60‐1.60)	1.19 (0.71‐1.99)
Microscopic infarcts	1.18 (0.87‐1.59)	1.00 (0.61‐1.64)	0.73 (0.43‐1.24)
Vascular disease pathology
Cerebral atherosclerosis	0.66 (0.46‐0.93)	1.93 (1.04‐3.59)	3.05 (1.49‐6.25)
Cerebral amyloid angiopathy	0.71 (0.53‐0.96)	2.15 (1.23‐3.74)	2.26 (1.25‐4.07)
Arteriolosclerosis	0.76 (0.55‐1.05)	1.21 (0.69‐2.14)	1.18 (0.63‐2.20)
Lewy bodies	1.12 (0.81‐1.54)	0.83 (0.44‐1.53)	0.78 (0.39‐1.56)
Hippocampal sclerosis	1.71 (0.96‐3.05)	0.38 (0.14‐1.04)	0.41 (0.15‐1.16)

^a Model adjusted for age, sex, education, income, smoking, alcohol consumption, physical activity, body mass index, heart disease, hypertension, diabetes, stroke, depression, and apolipoprotein E (APOE) ε4.

Aβ, amyloid beta.