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. 2022 Feb 9;18(12):2481–2492. doi: 10.1002/alz.12581

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© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Sup35NM induces focal tau pathology. Focal tau pathology induced around hippocampal inoculation canal and ipsilateral dorsal fornix upon Sup35NM inoculation. A, B, Gallyas stains. Note the characteristic focal grain‐like tau aggregates in proximity of the hippocampal injection canal upon Sup35NM inoculation (A, arrows indicate tau pathology along the inoculation canal). Granular tau pathology develops in the ipsilateral dorsal fornix of a SUP35NM‐seeded P301S mouse (B, right; arrow), but is absent in the contralateral fornix (B, left)