. 2022 Mar 15;19(1):97–106. doi: 10.1002/alz.12604

TABLE 3.

Correlation of delirium severity and relevant neuropsychological tests with normalized regional value in significantly hypometabolic regions

Region	Cognitive functions	Assessment	Correlation
Thalamus	Enables selective attention. Regulates arousal, consciousness, motor control, impulse inhibition.	Delirium index Right Left WMS III Mental control Right Left Trail Making Test B Right Left	ρ = −0.701, P = .001^* ρ = −0.705, P = .001^* ρ = −0.375, P = .104 ρ = −0.553, P = .011^* ρ = −0.510, P = .031^* ρ = −0.517, P = .028^*
rPCC	Attention, working memory, awareness, episodic memory retrieval. Critical part of the default mode network and limbic system.	Delirium index WMS III Mental control WAIS‐IV Digit Span Forwards	ρ = −0.469, P = .037^* ρ = −0.566, P = .009^* ρ = −0.412, P = .071
rSFC	Executive function. Cognitive and motor impulse control. Self‐awareness (including orientation).	Delirium index WMS III Mental control MMSE orientation score	ρ = −0.441, P = .051 ρ = −0.598, P = .005^* ρ = −0.320, P = .168
riLAT	Semantic knowledge; word, object, and facial recognition.	Delirium index Verbal fluency	ρ = −0.390, P = .089 ρ = −0.532, P = .016^*
lsPL	Sensorimotor integration. Selective attention to visual and tactile stimuli. Working memory.	Delirium index WMS III Mental control Trail making test B	ρ = −0.430, P = .058 ρ = 0.379, P = .099 ρ = −0.251, P = .316

Region

Cognitive functions

Assessment

Correlation

Thalamus

Enables selective attention.

Regulates arousal, consciousness, motor control, impulse inhibition.

Delirium index

Right

Left

WMS III Mental control

Right

Left

Trail Making Test B

Right

Left

ρ = −0.701, P = .001^*

ρ = −0.705, P = .001^*

ρ = −0.375, P = .104

ρ = −0.553, P = .011^*

ρ = −0.510, P = .031^*

ρ = −0.517, P = .028^*

rPCC

Attention, working memory, awareness, episodic memory retrieval.

Critical part of the default mode network and limbic system.

Delirium index

WMS III Mental control

WAIS‐IV Digit Span Forwards

ρ = −0.469, P = .037^*

ρ = −0.566, P = .009^*

ρ = −0.412, P = .071

rSFC

Executive function. Cognitive and motor impulse control. Self‐awareness (including orientation).

Delirium index

WMS III Mental control

MMSE orientation score

ρ = −0.441, P = .051

ρ = −0.598, P = .005^*

ρ = −0.320, P = .168

riLAT

Semantic knowledge; word, object, and facial recognition.

Delirium index

Verbal fluency

ρ = −0.390, P = .089

ρ = −0.532, P = .016^*

lsPL

Sensorimotor integration. Selective attention to visual and tactile stimuli.

Working memory.

Delirium index

WMS III Mental control

Trail making test B

ρ = −0.430, P = .058

ρ = 0.379, P = .099

ρ = −0.251, P = .316

Note: Correlation analysis was performed using Spearman's rank correlation coefficient.

Abbreviations: lsPL, left superior parietal cortex; MMSE, Mini‐Mental State Examination; rPCC, right posterior cingulate cortex; rSFC, right superior frontal cortex; riLAT, right infero‐lateral anterior temporal cortex; WMS III, Wechsler Memory Scale III; WAIS‐IV, Wechsler Adult Intelligence Scale.

P < .05.