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. Author manuscript; available in PMC: 2023 Apr 6.
Published in final edited form as: Front Dent Med. 2022 Nov 30;3:1009264. doi: 10.3389/fdmed.2022.1009264

FIGURE 4.

FIGURE 4

WIF1 locus is a candidate for human odontogenic phenotypes. (A) Visualization of the locus surrounding rs12229918 (chr5:134509987, hg19) and nearby fine-mapped variants associated with decreased tooth number and delayed tooth eruption by (83). Chromatin conformation heatmap demonstrated using HiC from a human CNCC culture line, from (109). STEs are shown as hg19 coordinates. Mouse craniofacial 18 state segmentations were generated as described in Methods from data from ENCODE (56); these rows are from mm10 coordinates of the orthologous locus containing the orthologous genes. Human craniofacial 18 state segmentations were obtained from (40). (B,C) Single cell transcriptomic analysis demonstrated the PEK-specific expression of Wif1 in the E14 mouse molar; p < 0.05, Wilcoxon test. (D–G) In situ hybridization images of Wif1, Hmga2, and Msrb3 were obtained from GenePaint http://genepaint.org/viewer/setInfo/MH772, https://genepaint.org/viewer/setInfo/EN837, and https://genepaint.org/viewer/setInfo/EH300, respectively (75). Enhancer assay images were obtained from VISTA (89).