Table 5.
Cost per life year saved of meningococcal C vaccination campaign in 0-17 year olds, results from univariate sensitivity analysis
| Parameter (base case)* | Range | Cost per life year saved |
|---|---|---|
| Incidence/case fatality ratio (high/medium) | High/high | £5 295 |
| High/low | £7 404 | |
| Low/high | £21 699 | |
| Low/medium | £25 459 | |
| Low/low | £30 169 | |
| Vaccine cost per dose (£12) | £8-£18 | £4 227-9 309 |
| Vaccine efficacy: | ||
| Toddlers (92%) | 65-98% | £6 212-6 480 |
| Children (95%) | 71-98% | £6 101-7 827 |
| Teenagers (97%) | 77-99% | £6 228-6 593 |
| Wastage (10%) | 0% | £5 705 |
| 10% GP/5% school | £6 085 | |
| 15%/15% | £6 537 | |
| Delivery costs: | ||
| GP (£4.30/£6.25) | £9 | £6 800 |
| School (31) | £3 | £6 842 |
| % of survivors with sequelae (7%) | 3-15% | £5 850-6 353 |
| Cost of sequelae: | ||
| Severe (£21 500/year) | £10 000-50 000 | £6 134-6 310 |
| Mild (£500/year) | £100-1000 | £6 240-6 275 |
| Hospital costs (see table 2) | ±20% | £6 055-6 464 |
| Cost outbreaks/year (£245) 500 | ±20% | £6 230-6 289 |
*
Under base case scenario cost per life saved is £6259.