Table 3. Adjusted risks of outcomes among key subgroups.
| Subgroup analyses | All-cause death | Composite of death and amputation | Amputation | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |
| Age >75 | 1.00 (0.98-1.02) | 0.89 | 1.00 (0.98-1.02) | 1.00 | 0.92 (0.88-0.96) | <0.01 |
| Age ≤75 | 1.00 (0.98-1.03) | 0.77 | 1.00 (0.97-1.03) | 1.00 | 0.99 (0.95-1.04) | 0.81 |
| CKD | 1.00 (0.98-1.02) | 0.89 | 1.00 (0.98-1.02) | 0.83 | 0.96 (0.93-1.00) | 0.06 |
| Diabetes | 0.99 (0.97-1.01) | 0.25 | 0.99 (0.97-1.01) | 0.42 | 0.96 (0.93-1.00) | 0.05 |
| Women | 1.01 (0.99-1.03) | 0.34 | 1.03 (1.00-1.05) | 0.04 | 0.97 (0.93-1.02) | 0.27 |
| Inpatients | 1.02 (0.96-1.04) | 0.13 | 1.03 (1.01-1.05) | 0.01 | 0.98 (0.94-1.02) | 0.31 |
| Outpatients | 0.98 (0.95-1.00) | 0.02 | 0.95 (0.93-0.98) | <0.01 | 0.90 (0.86-0.95) | <0.01 |
| Non-CLTI PAD | 1.00 (0.98-1.03) | 0.61 | 1.02 (1.00-1.05) | 0.88 | 0.96 (0.93-0.99) | 0.01 |
| CLTI | 1.00 (0.98-1.02) | 0.67 | 0.98 (0.96-1.00) | 0.07 | 0.93 (0.90-0.96) | <0.01 |
| CI: confidence interval; CKD: chronic kidney disease; CLTI: chronic limb-threatening ischaemia; PAD: peripheral artery disease | ||||||