Table 1. Commonly applicable principles of rigor, reproducibility, and transparency for Vanderbilt University Medical Center SRRs.

Methods are documented and systematically defined by use of peer-reviewed, consistently applied SOPs

Reagents are validated and properly maintained (ie, inventory controls and proper storage)

Software tools are validated

Instrumentation is maintained and calibrated

Positive/negative controls are justified, used, and appropriately interpreted

Batch effects are defined and reported

Statistical tests are appropriate to the data type and experiment

Quality control (QC) and sample data delivered to SRR user is clearly annotated, including interpretation of false positive/negative results. Results should be supplied in full unadulterated form for future analysis

Education provided to researchers for the purposes of accurate reporting of results

SRR staff are appropriately trained on new instrumentation/methods

Where applicable, limitations on the interpretation of resulting data are explained