Table 3. Subgroup analyses and meta regression results.
| Number of models | Sen1 | Spe2 | PLR | NLR | DOR | AUC | Meta regression | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pooled (95%CI) | I 2 | Pooled (95%CI) | I 2 | Pooled (95%CI) | I 2 | Pooled (95%CI) | I 2 | Pooled (95%CI) | I 2 | P | RDOR | |||
| Layers | 0.4878 | 0.74 | ||||||||||||
| ≤10 | 5 | 1.00 (1.00–1.00) | 97.80% | 0.99 (0.99–0.99) | 60.20% | 104.30 (70.94–153.36) | 65.70% | 0 (0.00–0.03) | 98.60% | 35609.58(4947.73–256287.76) | 93.80% | 0.9992 | ||
| 10–20 | 28 | 0.91(0.92–0.91) | 99.70% | 0.97 (0.97–0.96) | 99.80% | 7.40 (5.04–10.86) | 99.20% | 0.10 (0.07–0.16) | 99.60% | 52.47 (33.55–82.06) | 98.50% | 0.9861 | ||
| 20–50 | 11 | 0.94(0.93–0.95) | 96.70% | 0.95 (0.95–0.96) | 97.80% | 28.68 (10.64–77.28) | 98.30% | 0.04 (0.02–0.09) | 96.40% | 770.17 (163.74–3622.58) | 97.90% | 0.9927 | ||
| 50–100 | 7 | 0.93(0.91–0.94) | 85.40% | 0.98 (0.97–0.98) | 72.10% | 36.07 (30.09–43.24) | 50.80% | 0.10 (0.06–0.16) | 70.70% | 366.71 (219.09–613.82) | 59.70% | 0.9935 | ||
| >100 | 4 | 0.95 (0.94–0.97) | 64.80% | 0.98 (0.97–0.99) | 93.70% | 76.90 (21.55–274.39) | 90.70% | 0.04 (0.03–0.08) | 57.10% | 1967.84 (464.67–8333.64) | 84.40% | 0.9914 | ||
| Type of AMD | 0.1882 | 36.03 | ||||||||||||
| Single | 2 | 1.00 (0.99–1.00) | 0% | 0.99 (0.98–1.00) | 89.0% | 122.44 (6.08–2463.89) | 87.70% | 0.00 (0.00–0.02) | 0% | 107120.15 (8471.87–1354450.49) | 0% | NA3 | ||
| All | 54 | 0.94 (0.94–0.94) | 99.70% | 0.97 (0.97–0.97) | 99.70% | 20.61 (14.59–29.12) | 99.30% | 0.06 (0.04–0.09) | 99.70% | 306.14 (187.38–500.18) | 99.20% | 0.9915 | ||
| Architectures | 0.0004 | 0.19 | ||||||||||||
| ResNet | 13 | 0.94 (0.93–0.95) | 96.10% | 0.96 (0.95–0.96) | 97.60% | 34.66 (13.66–87.94) | 98.20% | 0.04 (0.02–0.08) | 96.00% | 951.18 (232.03–3899.24) | 97.70% | 0.9941 | ||
| VGG | 16 | 0.90 (0.90–0.89) | 99.60% | 0.91 (0.91–0.90) | 98.50% | 4.29 (3.25–5.67) | 98.30% | 0.19 (0.13–0.27) | 99.50% | 30.62 (21.91–42.79) | 96.90% | 0.8972 | ||
| Others | 26 | 0.99 (0.99–0.99) | 99.50% | 0.99 (0.99–0.99) | 99.40% | 86.04 (33.97–217.95) | 99.50% | 0.01 (0.00–0.08) | 99.70% | 7354.18 (1231.62–43913.09) | 99.40% | 0.9987 | ||
| Types of Images | 0.0002 | 0.12 | ||||||||||||
| OCT | 36 | 0.94 (0.94–0.94) | 99.80% | 0.97 (0.97–0.97) | 99.70% | 52.33 (32.57–84.10) | 99.50% | 0.03 (0.02–0.04) | 99.70% | 2209.74 (1113.02–4387.10) | 99.40% | 0.9982 | ||
| FP | 11 | 0.83 (0.81–0.84) | 96.90% | 0.96 (0.96–0.97) | 98.20% | 9.26 (3.74–22.92) | 99.10% | 0.18 (0.06–0.53) | 99.10% | 51.02 (13.37–194.69) | 97.70% | 0.9592 | ||
| OCT & FP | 8 | 0.84 (0.83–0.85) | 45.70% | 0.88 (0.87–0.89) | 87.00% | 4.38 (3.11–6.17) | 91.30% | 0.18 (0.15–0.20) | 30.00% | 28.80 (20.38–40.71) | 70.70% | 0.9176 | ||
| OPTOS | 1 | 1.00 (0.97–1.00) | 0% | 0.97 (0.94–0.99) | 0 | 34.95 (20.45–59.73) | 0% | 0 | 0 | 9371.15 (523.79–167661.33) | 0% | NA | ||
Sen: Sensitivity; Spe: Specificity; NA: not applicable.