Table 3:
Linear mixed effects regression results of the relationship between SSD in MCI and change in cognitive performance across the four year interval
| Interaction Between SSD and Time | ||||||
|---|---|---|---|---|---|---|
| Df | β Estimate | Standard Error | t-value | p-value | FDR p-value | |
| Alzheimer’s Disease Assessment Scale | 421 | 1.580 | 0.705 | 2.242 | 0.025* | 0.061 |
| WMS Logical Memory I | 245 | −0.300 | 0.287 | −1.046 | 0.297 | 0.445 |
| RAVLT Immediate Recall | 423 | 0.290 | 0.719 | 0.403 | 0.687 | 0.687 |
| WMS Logical Memory II | 244 | −0.698 | 0.274 | −2.525 | 0.011* | 0.054 |
| RAVLT Delayed Recall | 421 | 0.116 | 0.248 | 0.466 | 0.641 | 0.687 |
| Trail Making Test A | 421 | 4.681 | 1.970 | 2.376 | 0.018* | 0.054 |
| Trail Making Test B | 411 | 12.150 | 4.796 | 2.533 | 0.012* | 0.054 |
| Digit Symbol Substitution Test | 391 | −0.782 | 0.895 | −0.874 | 0.383 | 0.503 |
| Category Fluency (animals) | 424 | −0.855 | 0.354 | −2.418 | 0.016* | 0.054 |
| WAIS-III Digit Span Forwards | 392 | −0.190 | 0.154 | −1.233 | 0.218 | 0.374 |
| WAIS-III Digit Span Backwards | 390 | −0.133 | 0.164 | −0.809 | 0.419 | 0.503 |
| Boston Naming Test | 423 | −0.466 | 0.375 | −1.242 | 0.215 | 0.374 |
Notes: Longitudinal cognitive data was regressed on age, gender, years of education, APOE status, SSD group, time interval from baseline, and the interaction between SSD group and time interval from baseline using linear mixed models.
*
= p≤0.05
SSD=Subsyndromal Depression; WMS= Wechsler Memory Scale, RAVLT= Rey Auditory Verbal Learning Test, WAIS-III= Wechsler Adult Intelligence Scale-Third Edition