Table 5:

Linear mixed effects regression results of the relationship between SSD in MCI and change in cortical thickness in a priori regions of interest over the four-year study interval (df=341)

	Interaction Between SSD and Time
	β Estimate	Standard Error	t-value	p-value	FDR p-value
Frontal Lobe	−0.020	0.007	−2.648	0.008*	0.040
Anterior Cingulate	−0.036	0.009	−3.786	<0.001*	<0.001
Precuneus	−0.009	0.007	−1.238	0.217	0.380
Cuneus	−0.003	0.005	−0.626	0.532	0.760
Posterior Cingulate	−0.015	0010	−1.518	0.130	0.320
Temporal Lobe	−0.018	0.010	−1.706	0.089	0.300
Parahippocampus	−0.012	0.010	−1.212	0.226	0.380
Hippocampus	−5.924	14.530	−0.408	0.684	0.860
Entorhinal Cortex	0.001	0.019	0.042	0.967	0.970

Note: Longitudinal cortical atrophy was regressed on age, gender, APOE status, SSD group, time interval from baseline, and the interaction between SSD group and time interval from baseline using linear mixed models.

^*= p<0.05

SSD=Subsyndromal Depression