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. 2023 Apr 7;26(5):106582. doi: 10.1016/j.isci.2023.106582

Figure 2.

Figure 2

Fc-receptor binding antibody profiles across SARS-CoV-2 variants of concern

Individuals received a three-dose regimen of the BNT162b2 vaccine. Samples were taken approx. 2 weeks after the second dose (post second, n = 18), before the third dose approx. 8 months after the second dose (pre third, n = 14) and approx. 2 weeks after the third dose (post third, n = 22). Binding to FcγR2a (A), FcγR2b (B), FcγR3a (C), FcγR3b (D), and FcαR (E) of D614G (WT), alpha (B.1.1.7), beta (B.1.351), delta (B.1.617.2) variants of concern, and omicron (B.1.1.529) BA.1 and BA.2 subvariants spike specific antibodies were measured by Luminex. The average value of technical replicates is shown. The data were corrected for background and negative values were set to 100 for graphing purposes. A two-sided paired Wilcoxon test with a Benjamini-Hochberg post-test correcting for multiple comparisons was used to test for statistical differences between BA1 and BA2 titers, respectively. P-values are shown above each dataset. Horizontal lines indicate median and error bars the 95% confidence interval. See also Figures S3 and S4.