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. 2023 Apr 7;26(5):106582. doi: 10.1016/j.isci.2023.106582

Figure 3.

Figure 3

Fc functionality of BNT162b2-induced antibodies is superior to BA.1 compared to BA.2 antigen

Antibody-dependent complement deposition (ADCD) (A), Neutrophil phagocytosis (ADNP) (B), Cellular monocyte phagocytosis (ADCP) (C), or NK cell activation (marked by CD107a expression) (D) of D614G, omicron (B.1.1.529) BA.1 or BA.2 specific antibodies was analyzed in BNT162b2 recipients at approx. 2 weeks after the second dose (post second, n = 18), before the third dose approx. 8 months after the second dose (pre third, n = 14) and approx. 2 weeks after the third dose (post third, n = 22). The average value of two donors is shown for ADNP and ADNKA or of two technical replicates for ADCD and ADCP. The data were corrected for background and negative values were set to 1 for graphing purposes. A two-sided paired Wilcoxon test with a Benjamini-Hochberg post-test correcting for multiple comparisons was used to test for statistical differences between BA1 and BA2 titers, respectively. P-values are shown above each dataset. Horizontal lines indicate median and error bars the 95% confidence interval. See also Figures S5–S8.