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. 2023 Apr 7;26(5):106582. doi: 10.1016/j.isci.2023.106582

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© 2023 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

BNT162b2 induces distinct BA.1 and BA.2 specific responses

A machine learning model was built using BA.1 and BA.2 spike specific features in BNT162b2 vaccinated individuals post third dose (n = 22).

(A) A minimal set of LASSO selected features was used to discriminate between humoral responses in a PLS-DA analysis. Each point represents an individual’s humoral response for BA.1 (purple) and BA.2 (red).

(B) Selected features were ordered according to their variable importance in projection (VIP) score (purple = enriched for BA.1 antigen).