Figure 1.

Overall survival of patients stratified according to the TP53 mutation load. CLL cases from a retrospective cohort originally published in⁷ were reclassified according to the standard cutoff for TP53 mutation evaluation (≥10% VAF), to the cutoff suggested by¹ (≥5% VAF), and to the <5% VAF cutoff, as discussed in the present commentary. (A) Kaplan-Meier curves comparing OS computed from the date of TP53 mutation evaluation⁷ of CLL 1220 patients stratified into 4 classes according to the TP53 mutational load: TP53 wild-type cases (green line, n = 1052), cases with <5% VAF of TP53 mutation (blue line, n = 64), cases with VAF of TP53 mutations between 5.0% and 10.0% (purple line, n = 12), and cases with ≥10.0% VAF of TP53 mutation (red line, n = 92). (B) Kaplan-Meier curves comparing OS computed from the date of treatment⁷ of 552 treated CLL patients stratified into 4 classes according to the TP53 mutational load: TP53 wild-type cases (green line, n = 449), cases with <5% VAF of TP53 mutation (blue line, n = 38), cases with VAF of TP53 mutations between 5.0% and 10.0% (purple line, n = 4), and cases with ≥10.0% VAF of TP53 mutation (red line, n = 61). P values refer to the log-rank test. CLL = chronic lymphocytic leukemia; OS = overall survival; VAF = variants with allele frequency.