TABLE 1.
Participant characteristics
| Nonresponders (n=16) | Responders (n=15) | Controls (n=15) | p-value | |
|---|---|---|---|---|
| Age (y) | 60 (56–66) | 65 (54–71) | 57 (31–74) | 0.2 |
| No. of women (%) | 14 (87.5%) | 15 (94%) | 15 (100%) | 0.4 |
| Disease duration (y) | 10.8 (6.7–13.8) | 8.3 (3.2–12.5) | — | 0.3 |
| UDCA dose (mg/kg/day) | 14.3 (13.2–16.0) | 11.9 (10.3–13.8) | — | 7.2×10−3 |
| ALP (U/L) | 467.5 (383.8–541.5) | 97.0 (83.5–120.0) | 64 (53–78) | 2.3×10−6 |
| ALP/ULN | 3.7 (3.1–4.5) | 0.8 (0.7–1.0) | 0.5 (0.4–0.6) | 2.3×10−6 |
| ALT (U/L) | 60.5 (47–81.5) | 31 (19.5–49.5) | 19 (16–28) | 5.3×10−3 |
| Bilirubin (μmol/L) | 12 (9.8–19.3) | 7 (6–10) | 10 (9–11) | 1.4×10−3 |
| Albumin (g/L) | 38 (36–40.3) | 45.0 (42.5–47.5) | 39 (37–40) | 4.5×10−4 |
| Platelets (109/L) | 250 (203.5–303.5) | 245 (190–322.5) | 224 (198–300) | 0.9 |
| Transient elastography (kPa) | 6.8 (5.6–8.0) | 7.6 (5.0–13.9) | — | 0.7 |
Notes: Median values (interquartile range) are shown for all parameters except for the number (percentage) of women.
Statistical tests were ANOVA for comparison of age across all 3 groups; the Kruskal-Wallis chi-square test to compare the proportion of women in each group; and a 2-tailed Mann-Whitney test to compare all other parameters in nonresponders versus responders.
Abbreviations: ALP, alkaline phosphatase; UDCA, Ursodeoxycholic acid.