TABLE 3.

Pathway enrichment

				Enrichr
PBMC subset	Module	Comparison group direction of effect in WGCNA		Hallmark pathway	p	q
CD14+	Salmon	—	—	TNFα signalling through NF-кB	1.75×10−52	7.89×10−51
		—	—	Apoptosis	3.45×10−6	3.58×10−5
			NR vs. CN	mTORC1 signalling	4.78×10−6	3.58×10−5
		—	—	KRAS signalling up	4.78×10−6	3.58×10−5
		—	—	IL-2/STAT5 signalling	2.56×10−6	1.51×10−4
		—	—	IFNγ response	2.69×10−6	1.51×10−4
TH1	Yellow		NR vs. CN	TNFα signalling via NF-кB	2.35×10−39	1.08×10−37
			R vs. CN	p53 pathway	2.36×10−4	3.63×10−3
			CS vs. CN	Apoptosis	5.30×10−4	6.10×10−3
	Green	—	—	—	—	—
		—	IL-2/STAT5 signalling	2.32×10−4	2.77×10−3	—
			R vs. CN	IFNγ response	2.46×10−4	2.77×10−3
			NR vs. CN	IL-6/JAK/STAT3 signalling	1.83×10−3	9.94×10−3
			CS vs. CN	TNFα signalling through NF-кB	1.99×10−3	9.94×10−3
		—	—	KRAS signalling up	1.99×10−3	9.94×10−3
TH17	Purple		NR vs. CN	TNFα signalling through NF-кB	3.35×10−6	8.71×10−5
			R vs. CN	—	—	—
			CS vs. CN	—	—	—
	Red		NR vs. CN	TNFα signalling via NF-кB	2.04×10−30	9.40×10−29
			CS vs. CN	IFNγ response	3.72×10−6	4.27×10−5
			R vs. CN	IL-2/STAT5 signalling	1.52×10−5	1.40×10−4
	Magenta		R vs. CN	KRAS signalling up	1.13×10−9	2.08×10−8
		—	—	IFNγ response	6.48×10−5	4.79×10−4
		—	—	IL-6/JAK/STAT3 signalling	1.40×10−4	8.60×10−4
TREG	Green		R vs. CN	TNFα signalling through NF-кB	1.74×10−2	6.43×10−1
	Brown		R vs. NR	KRAS signalling up	1.44×10−6	6.77×10−5
			NR vs. CN	IL-6/JAK/STAT3 signalling	8.10×10−6	1.27×10−4
			R vs. CN	IL-2/STAT5 signalling	1.33×10−5	1.36×10−4
			CS vs. CN	TNFα signalling through NF-кB	4.27×10−5	2.87×10−4
B	Black		R vs. CN	TNFα signalling through NF-кB	2.60×10−4	1.09×10−2
			CS vs. CN	—	—	—

Notes: Enrichment of Hallmark pathways was evaluated using the platform, Enrichr.

Pathways enriched at q<0.05 are shown.

The direction of effect for the comparison groups is highlighted.

indicates positive correlation,indicates negative correlation.

q is the FDR corrected p-value.

▴▴indicates moderate correlation ▴▴▴indicates strong correlation.

Abbreviation: FDR, false discovery rate; NR, non-responder.