Skip to main content
. Author manuscript; available in PMC: 2023 Apr 7.
Published in final edited form as: Eur Respir J. 2022 Jul 13;60(1):2101581. doi: 10.1183/13993003.01581-2021

FIGURE 3.

FIGURE 3

GLPG2196 reverses airway remodelling in smoke-exposed ferrets. Semi-automated measurements were derived from image slices (n~100) for each animal at one airway per apical lobe between the fourth and sixth. a) Semi-automated measurements of airway bronchial wall thickness (BWT) and b) BWT/luminal diameter (LD) ratio of smoke-exposed ferrets administered vehicle or GLPG2196. Comparisons by unpaired t-test. Data are shown as box and whisker plots with Tukey or minimum-to-maximum whiskers, where appropriate. c) Semi-automated measurements of BWT pre- and post-treatment with vehicle or GLPG2196 in smoke-exposed ferrets (n=3, ordinary one-way ANOVA with post hoc Tukey. Each line represents a ferret. d) Semi-automated measurements of BWT/LD ratio pre- and post-treatment with vehicle or GLPG2196 in smoke-exposed ferrets (n=4, Wilcoxon rank-sum test). e, f) Semi-automated scatter plots of the square root of BWT (√WA) versus airway luminal perimeter of a smoke-exposed vehicle-treated and a smoke-exposed GLPG2196-treated ferret (e) and of a smoke-exposed ferret pre- and post-treatment with GLPG2196 (f). Plots include data from n=4 ferrets per group. g) Semi-automated calculated √WA of the theoretical 4 mm perimeter airway (Pi4) for each smoke-exposed ferret pre- and post-treatment with vehicle or GLPG2196 (n=4, paired t-test). #: p=0.0629; ##: p=0.0125; *: p<0.05; **: p<0.01; ****: p<0.0001.