Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 6;11(7):e15652. doi: 10.14814/phy2.15652

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Effect of 6‐week long administration of probenecid on the ADPKD development in the 1‐year‐old male Pkd1 ^RC/RC mice. (a) Representative curves of inulin blood plasma show faster clearance in probenecid‐treated versus control mice. (b) Summary graph of glomerular filtration rate (N = 11 in each group). (c) Representative transverse kidney sections in the vehicle‐ and probenecid‐treated groups. (d) Summary graph of cyst area percentage related to total slice area. (e) Smaller renal size after the treatment with probenecid, detected with two kidneys / total body weight percentage. *p < 0.05, **p < 0.01 per unpaired t‐test. N = 13 (vehicle), N = 15 (probenecid).