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Probabilities of target attainment of empirical therapy using the current dosing regimen with a 4-hour extended infusion for patients with CLCR of 0 - 130 mL/min when there is no target trough concentration (Cmin) and when the target Cmin is <20 mg/L or <7.5 mg/L. Bars indicate the MIC distribution for Escherichia coli (left), Klebsiella pneumoniae (middle), and Pseudomonas aeruginosa (right).
MIC, minimum inhibitory concentration.
