Table 2. Population PK parameter estimates for cefepime.
| Parameter | Estimates | RSE (%) [Shrinkage (%)] | Bootstrap median (95% confidence intervals) | ||
|---|---|---|---|---|---|
| Structural model | |||||
| CL = θ1 × (CG/77.21)θ2 | |||||
| θ1 (L/h) | 6.60 | 7.91 | 6.63 (5.55 – 7.64) | ||
| θ2 | 0.656 | 10.7 | 0.650 (0.438 – 0.796) | ||
| V1 (L) | 13.3 | 9.79 | 13.4 (10.8 – 16.5) | ||
| Q (L/h) | 16.5 | 18.7 | 16.2 (9.59 – 23.7) | ||
| V2 (L) | 13.0 | 10.6 | 12.8 (9.87 – 16.3) | ||
| Interindividual variability | |||||
| CL (%) | 33.7 | 25.2 [0.000] | 32.0 (17.0 – 46.8) | ||
| V1 (%) | 34.1 | 24.9 [11.2] | 32.9 (7.52 – 49.5) | ||
| Q (%) | 50.8 | 18.4 [19.6] | 46.5 (0.000 – 65.8) | ||
| V2 (%) | 40.1 | 21.2 [8.84] | 38.6 (16.7 – 54.3) | ||
| Residual variability | |||||
| Proportional error (%) | 7.62 | 9.43 | 7.61 (6.10 – 9.23) | ||
PK, pharmacokinetics; RSE, relative standard error; CL, total clearance; V1, central volume of distribution; Q, intercompartmental clearance between V1 and V2; V2, peripheral volume of distribution.