Table 1. Characteristics of the study population after propensity score matching.
| Variables | Matched controls (n = 40,512) | Patients with AD (n = 40,512) | P value | |
|---|---|---|---|---|
| Sex | 0.7584 | |||
| Male | 16,478 (40.67) | 16,435 (40.57) | ||
| Female | 24,034 (59.33) | 24,077 (59.43) | ||
| Age (yr) | 0.9971 | |||
| 20–29 | 5,280 (13.03) | 5,274 (13.02) | ||
| 30–39 | 8,381 (20.69) | 8,411 (20.76) | ||
| 40–49 | 8,825 (21.78) | 8,826 (21.79) | ||
| 50–59 | 8,426 (20.80) | 8,394 (20.72) | ||
| 60–69 | 5,410 (13.35) | 5,385 (13.29) | ||
| 70–79 | 3,305 (8.16) | 3,311 (8.17) | ||
| ≥ 80 | 885 (2.18) | 911 (2.25) | ||
| Household income | 0.9403 | |||
| Low (0–2) | 4,113 (10.15) | 4,167 (10.29) | ||
| Medium–low (3–5) | 9,299 (22.95) | 9,288 (22.93) | ||
| Medium–high (6–8) | 11,675 (28.82) | 11,666 (28.80) | ||
| High (9–10) | 15,425 (38.08) | 15,391 (37.99) | ||
| Region of residence | 0.7948 | |||
| Urban | 19,521 (48.19) | 19,558 (48.28) | ||
| Rural | 20,991 (51.81) | 20,954 (51.72) | ||
| Comorbidity | ||||
| Hypertension | 6,225 (15.37) | 6,216 (15.34) | 0.9301 | |
| Diabetes | 2,233 (5.51) | 2,259 (5.58) | 0.6898 | |
| Hyperlipidemia | 2,227 (5.50) | 2,220 (5.48) | 0.9140 | |
| CCI | < 0.0001 | |||
| 0 | 34,206 (84.43) | 32,417 (80.02) | ||
| 1 | 4,418 (10.91) | 5,645 (13.93) | ||
| 2 | 1,357 (3.35) | 1,696 (4.19) | ||
| ≥ 3 | 531 (1.31) | 754 (1.86) | ||
| Smoking status | < 0.0001 | |||
| Current | 8,256 (20.38) | 7,826 (19.32) | ||
| Former | 4,384 (10.82) | 4,808 (11.87) | ||
| Never | 27,872 (68.80) | 27,878 (68.81) | ||
| BMI (kg/m2) | 0.9056 | |||
| < 18 | 1,263 (3.12) | 1,283 (3.17) | ||
| 18–24.9 | 26,897 (66.39) | 26,908 (66.42) | ||
| ≥ 25 | 12,352 (30.49) | 12,321 (30.41) | ||
| Co-medications | ||||
| ACEIs | 485 (1.20) | 510 (1.26) | 0.4252 | |
| ARBs | 3,665 (9.05) | 3,879 (9.57) | 0.0097 | |
| BBs | 1,619 (4.00) | 1,845 (4.55) | < 0.0001 | |
| CCBs | 4,078 (10.07) | 4,215 (10.40) | 0.1123 | |
| Diuretics | 2,947 (7.27) | 2,980 (7.36) | 0.6561 | |
| Insulin | 25 (0.06) | 29 (0.07) | 0.5861 | |
| Hypoglycemic drugs other than insulin | 2,230 (5.50) | 2,309 (5.70) | 0.2275 | |
| Statins | 2,970 (7.33) | 3,454 (8.53) | < 0.0001 | |
| Lipid-lowering drugs other than statin | 558 (1.38) | 702 (1.73) | < 0.0001 | |
| Antiplatelets | 2,381 (5.88) | 2,993 (7.39) | < 0.0001 | |
| Anticoagulants | 58 (0.14) | 116 (0.29) | < 0.0001 | |
| Antidepressants | 657 (1.62) | 1,055 (2.60) | < 0.0001 | |
Variables are presented as numbers (%), and the P value was derived from the χ2 test.
AD, atopic dermatitis; CCI, Charlson comorbidity index; BMI, body mass index; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BB, beta blocker; CCB, calcium channel blocker.