Table 2. Comparison of the risk for CVDs between patients with AD and matched controls.
| Variables | No. | Event (%) | Crude HR (95% CI) | P value | Adjusted HR (95% CI)* | P value | ||
|---|---|---|---|---|---|---|---|---|
| CVDs | ||||||||
| AD | 40,512 | 2,235 (5.52) | 1.46 (1.37–1.55) | < 0.0001 | 1.42 (1.33–1.52) | < 0.0001 | ||
| Matched controls | 40,512 | 1,640 (4.05) | Reference | Reference | ||||
| Ischemic heart disease | ||||||||
| AD | 40,512 | 1,310 (3.23) | 1.51 (1.39–1.65) | < 0.0001 | 1.47 (1.35–1.60) | < 0.0001 | ||
| Non-AD | 40,512 | 920 (2.27) | Reference | Reference | ||||
| Angina pectoris | ||||||||
| AD | 40,512 | 1,171 (2.89) | 1.54 (1.41–1.68) | < 0.0001 | 1.49 (1.36–1.63) | < 0.0001 | ||
| Matched controls | 40,512 | 810 (2.00) | Reference | Reference | ||||
| MI | ||||||||
| AD | 40,512 | 243 (0.60) | 1.45 (1.20–1.76) | 0.0002 | 1.40 (1.15–1.70) | 0.0009 | ||
| Matched controls | 40,512 | 178 (0.44) | Reference | Reference | ||||
| Stroke | ||||||||
| AD | 40,512 | 880 (2.17) | 1.37 (1.24–1.51) | < 0.0001 | 1.30 (1.18–1.44) | < 0.0001 | ||
| Matched controls | 40,512 | 682 (1.68) | Reference | Reference | ||||
| Ischemic stroke | ||||||||
| AD | 40,512 | 758 (1.87) | 1.41 (1.27–1.57) | < 0.0001 | 1.34 (1.20–1.49) | < 0.0001 | ||
| Matched controls | 40,512 | 570 (1.41) | Reference | Reference | ||||
| Hemorrhagic stroke | ||||||||
| AD | 40,512 | 262 (0.65) | 1.30 (1.09–1.56) | 0.0043 | 1.26 (1.05–1.52) | 0.0118 | ||
| Matched controls | 40,512 | 215 (0.53) | Reference | Reference | ||||
CVD, cardiovascular disease; HR, hazard ratio; CI, confidence interval; AD, atopic dermatitis; MI, myocardial infarction.
*Adjusted for sex, age, household income, region of residence, body mass index, smoking status, comorbidities (hypertension, diabetes, and hyperlipidemia), Charlson comorbidity index, and co-medications.