Table 3. Comparison of the risk for CVDs between patients with severe and non-severe AD.
| Variables | No. | Event (%) | Crude HR (95% CI) | P value | Adjusted HR (95% CI)* | P value | ||
|---|---|---|---|---|---|---|---|---|
| CVDs | ||||||||
| Severe AD | 19,621 | 1,285 (6.55) | 1.67 (1.53–1.82) | < 0.0001 | 1.62 (1.48–1.77) | < 0.0001 | ||
| Non-severe AD | 20,082 | 824 (4.10) | Reference | Reference | ||||
| Ischemic heart disease | ||||||||
| Severe AD | 20,164 | 742 (3.68) | 1.76 (1.57–1.98) | < 0.0001 | 1.70 (1.51–1.92) | < 0.0001 | ||
| Non-severe AD | 20,455 | 451 (2.20) | Reference | Reference | ||||
| Angina pectoris | ||||||||
| Severe AD | 20,230 | 676 (3.34) | 1.77 (1.56–2.00) | < 0.0001 | 1.70 (1.50–1.93) | < 0.0001 | ||
| Non-severe AD | 20,498 | 408 (1.99) | Reference | Reference | ||||
| MI | ||||||||
| Severe AD | 20,772 | 134 (0.65) | 1.74 (1.32–2.29) | < 0.0001 | 1.63 (1.23–2.15) | 0.0007 | ||
| Non-severe AD | 20,824 | 82 (0.39) | Reference | Reference | ||||
| Stroke | ||||||||
| Severe AD | 20,418 | 488 (2.39) | 1.56 (1.36–1.80) | < 0.0001 | 1.45 (1.26–1.67) | < 0.0001 | ||
| Non-severe AD | 20,575 | 331 (1.61) | Reference | Reference | ||||
| Ischemic stroke | ||||||||
| Severe AD | 20,497 | 409 (2.00) | 1.56 (1.34–1.82) | < 0.0001 | 1.43 (1.22–1.67) | < 0.0001 | ||
| Non-severe AD | 20,629 | 277 (1.34) | Reference | Reference | ||||
| Hemorrhagic stroke | ||||||||
| Severe AD | 20,755 | 151 (0.73) | 1.52 (1.19–1.95) | 0.0009 | 1.47 (1.15–1.89) | 0.0025 | ||
| Non-severe AD | 20,800 | 106 (0.51) | Reference | Reference | ||||
CVD, cardiovascular disease; AD, atopic dermatitis; HR, hazard ratio; CI, confidence interval; MI, myocardial infarction.
*Adjusted for sex, age, household income, region of residence, body mass index, smoking status, comorbidities (hypertension, diabetes, and hyperlipidemia), Charlson comorbidity index, and co-medications.