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. 2023 Mar 2;42(15):1224–1232. doi: 10.1038/s41388-023-02638-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Our data are not consistent with the predictions of the rare codon model. The sweet spot for oncogenic Ras signaling will be influenced by cellular and tissue context. Often but not always, the most abundance isoform sits in the sweet spot when it becomes mutated.