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Lyophilization preserves bioactivity of HOTAIR-loaded MSC EVs Lyophilization and storage at RT for 4 weeks preserved the ability of HOTAIR-loaded BDMSC EVs to accelerate healing in a db/db mouse wound healing model over the course of 2 weeks. (A) Quantification of wound closure as determined by digital planimetry; all values are expressed as mean ± standard deviation (**p < 0.01). (B) Images of wounds at the indicated time points.
