References	Test subjects	Number of volunteers	Compound	Dosage	Delivery	Method of assessment	Outcome
Firoozeei et al. 2021)	Elderly hospitalized for acute care	31	Lavender oil	“One drop” on “a pillow”	Olfactory	Observation	Enhanced sleep
Mameneh et al. 2021)	Healthy infants	30	Lavender oil	Data not shown/aromatic bath oil	Olfactory, trans dermal	Observation, salivary cortisol levels	Enhanced sleep, decreased stress
Fismer and Pilkington 2012)	Healthy adults	31	Lavender oil	Aromatic exposure in 2 min intervals	Olfactory	Polysomnographic recording	Enhanced sleep
Boelens 1995)	Healthy adult dental patients	343	Lavender oil	5 Drops of oil in10 mL diffused by candle	Olfactory	Modified dental anxiety scale, state trait anxiety inventory	Decreased anxiety
Smigielski et al. 2009)	Healthy adults	12 and 24	R-( −)- and S- ( +)-linalool	20 µL of various oil dilutions (between 0.003 and 30% of air)	Olfactory	Survey, electroencephalographic activity	Increased favorable impressions
Góra et al. 2005)	Healthy adults	24	R-( −)- and S- ( +)-linalool	2.7 mg/m3 (R-( −) linalool) and 9.8 mg/m3 (S-( +)-linalool) of air in room	Olfactory	Autonomic and endocrine system parameters including salivary cortisol levels	Decreased anxiety
Lis-Balchin and Hart 1999)	Dermatitis patients	1511	Linalool, myrcene, and caryophyllene, and oxidation products	0.5–3.9% of oxidized terpenoids, 20% non-oxidized linalool in petrolatum	Transdermal patch test	Observation of skin irritation	Contact allergy to terpenoid oxidation products
Mills et al. 1995)	Dermatitis patients	1511	Linalool, oxidized linalool	2–11% Petrolatum (0.80–4.4 mg/cm2)	Transdermal l patch test	Observation according to the International Contact Dermatitis Research Group guidelines	Contact allergy to oxidized linalool
Haag and Gould 1994)	Elderly hospitalized for dementia	21	Lavender oil	Data not shown	Olfactory, trans dermal	Observation of motor behaviors	Decreased agitation
Lantry et al. 1997)	Elderly hospitalized for dementia	15	Lavender oil	2% of air	Olfactory	Pittsburgh agitation scale	Decreased agitation
Clegg et al. 1982)	Elderly hospitalized for dementia	36	Lavender oil	3.5% of aqueous solution	Trans dermal	Mini-mental state examination	Increased cognition
Hohmann et al. 1999)	Elderly hospitalized in ICU short term	122	Lavender oil	1.0% of aqueous solution	Olfactory, trans dermal	Behavioral observation, blood pressure, heart rate, breath rate	Increased sedation
Perrucci et al. 1994)	Healthy adult females	96	Lavender oil	Cotton wood soaked with three drops of oil in a jar	Olfactory	Galvanic skin response	Increased relaxation
O’Brien 1999)	Healthy infants	45	Lavender oil	10% v/v	Olfactory	Electroencephalographic activity	Increased positive affect
Akhondzadeh et al. 2003)	Healthy adults	40	Lavender oil	10% v/v	Olfactory	Electroencephalographic activity	Increased positive mood, sedation
Kashani et al. 2011)	Healthy adult males	30	Lavender oil	“Four oil drops diluted with 20 mL hot water”	Olfactory	Coronary flow velocity reserve	Increased relaxation, coronary circulation
Mayaud et al. 2008)	Adult male	1	Lavender oil	2% in peanut oil	Trans dermal	Gas chromatography analysis of blood	Rapid accumulation (peak 20 min) and expulsion (90 min)
Hanamanthagouda et al. 2010)	Healthy adults	4	1,8-Cineole	Air passing over 4 mL for 20 min	Olfactory	Gas chromatography analysis of blood	Accumulation (peak ~ 18 min) and expulsion half-life (104.6 min) of 1,8 cineole