Table 2.

Systemic changes during each CVR paradigm.

	EtCO2 (mmHg)	MAP (mmHg)	HR (beats/minute)
	Delta from baseline
HC	13.0 (7.80, 19.0)+*	4.9 (1.9, 10.3)+	2.1 (-3.1, 4.7)*
BH	7.5 (5.9, 9.2)+	8.0 (5.6, 11.6)+	11.5 (9.1, 19.2)+
	Range: median (IQR)
Resting state	6.5 (5.3, 8.8)	1.9 (1.4, 2.3)	3.3 (2.9, 5.3)

Median (interquartile range) change in ${\mathrm{EtCO}}_2$, mean ABP (MAP) and heart rate (HR) for each experimental paradigm. For HC, this change reflects the steady state change from room-air inhalation, and for BH, this change reflects the peak increase during BH. For RS, the median (IQRs) of the range (max – min over the 10-min period) is reported. ⁺ denotes significant difference from baseline ($p<0.05$); * denotes significant difference between HC and BH ($p<0.05$).