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. 2023 Apr 6;13:5633. doi: 10.1038/s41598-023-32738-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Skin wrinkle parameters, (A) surface; (B) Volume; (C) Ra; (D) Rz measured at two skin sites as the corner of eye and under cheek bone in the test and placebo groups at baseline (), after 30 d () and 60 d () of application. (Mean ± SD,*p < 0.05, **p < 0.001 vs. baseline; ^†p < 0.05, ^††p < 0.001 test vs. placebo group).

Inline graphic — Skin wrinkle parameters, (A) surface; (B) Volume; (C) Ra; (D) Rz measured at two skin sites as the corner of eye and under cheek bone in the test and placebo groups at baseline (), after 30 d () and 60 d () of application. (Mean ± SD,*p < 0.05, **p < 0.001 vs. baseline; ^†p < 0.05, ^††p < 0.001 test vs. placebo group).