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. 2023 Mar 24;11:1098999. doi: 10.3389/fped.2023.1098999

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© 2023 Bhavsar, Olsen, Løkke, Koster, Flægstad and Einvik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-323a-3p induces G1-cell cycle arrest and apoptosis in neuroblastoma cells. (A) Kelly and SH-SY5Y cell lines were transfected with miR-323a-3p or NC mimics and cell cycle distribution was measured by flow cytometry assay. Data is presented as mean ± SD of three independent experiments. (B) Total PARP and PARP-cleavage (represents apoptosis) was detected on western blot in Kelly, SH-SY5Y and BE(2)-C cell lines transfected with miR-323a-3p. Quantification of cleaved PARP protein levels on the western blots (n = 3). (C) (B) BCL2 was detected on western blot in Kelly, SH-SY5Y and BE(2)-C cell lines transfected with miR-323a-3p. Quantification of BCL2 protein levels on the western blots (n = 3). Data is presented as mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the NC. SD, standard deviation; NC, negative control; miR, microRNA; c-PARP, cleaved PARP.