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. 2023 Mar 24;11:1098999. doi: 10.3389/fped.2023.1098999

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© 2023 Bhavsar, Olsen, Løkke, Koster, Flægstad and Einvik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STAT3 is a direct target of miR-323a-3p in neuroblastoma. (A) The putative binding site of miR-323a-3p (nucleotides 1,097 to 1,103) in the 3′UTR of STAT3 was mutated as shown in the figure with bold and italics. (B) Dual-luciferase reporter assay demonstrating the luciferase activity of a construct with a wild-type or a mutated 3′UTR of STAT3 in SH-SY5Y transfected with miR-323a-3p or NC mimics. Data is presented as mean ± SD of three independent experiments, each repeated in triplicates. **P < 0.01 vs. the NC. SD, standard deviation; miR, microRNA; NC, negative control; STAT3, signal transducer and activator of transcription; ORF, open Reading frame; UTR, untranslated region; wt, wild-type; MUT, mutated.