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. 2023 Mar 24;17:1052079. doi: 10.3389/fnins.2023.1052079

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Copyright © 2023 Bühler, Power Guerra, Müller, Wolkenhauer, Düffer, Vollmar, Kuhla and Wolfien.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated Plus Maze (EPM) analysis. (A) Moved distance (cm), (B) mean velocity (cm/s), (C) number of visits (counts) on open arm (n), (D) number of visits (counts) in closed arm (n). Analyses were done with the EthoVision software. The group size was as follows: n(wt) = 45 (A–C) and 44 (D), n(ob/ob) = 45. Significance of differences between the groups were tested by unpaired Student’s t-test. Statistical significance was set at ****p < 0.0001.