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. 2023 Mar 23;10:1089159. doi: 10.3389/fmed.2023.1089159

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Copyright © 2023 Yu, Choi, Rim, Kim, Bekheirnia, Swartz, Dai, Gu, Lee, Nishinakamura, Hildebrandt, Bekheirnia and Gee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADAMTS9 influences the Wnt/PCP pathway and regulates the localization of junction proteins. (A) Dot plot showing the expression of Wnt/PCP pathway genes in podocyte clusters across control and ADAMTS9 knockout (KO) organoids. (B) Immunostaining of kidney organoids showing NEPHRIN and PODOCIN localization in ADAMTS9 KO podocytes. White arrows indicate NEPHRIN and PODOCIN localization. White arrows indicate NEPHRIN and PODOCIN localization. NEPHRIN and PODOCIN were observed in the lateral side of podocytes in control organoids, but not in ADAMTS9 KO organoids. NEPHRIN and PODOCIN were localized only in the basal side of podocytes in ADAMTS9 KO organoids. Scale bars, 10 μm. (C) Electron microscopy images of podocytes in kidney organoids. Ladder-like structures were observed in both control and ADAMTS9 KO podocytes. White scale bars, 500 nm. Black scale bars, 100 nm.