Table 4.

Psychiatric disorders and self-rated chronic fatigue syndrome onset by baseline fatigue.

Self-reported lifetime psychiatric disorders
Baseline	No pre-existing fatigue			Fatigued “most or all of the time”
	No CFS n = 124,223	CFS onset n = 292	P value adjusted for age sex	No CFS n = −10,025	CFS onset n = 192	P value adjusted for age and sex	Baseline CFS n = 1983
Burnout	8.4%	16.4%	p < 0.001	16.7%	22.9%	0.051	26.9%
Depression	10.0%	26.0%	p < 0.001	25.9%	47.9%	p < 0.001	39.8%
Agoraphobia	0.5%	1.7%	0.005	1.5%	1.6%	Ns	2.9%
Panic disorder	3.0%	8.6%	p < 0.001	7.4%	15.1%	p < 0.001	11.8%
Other anxiety disorder	3.1%	7.5%	p < 0.001	7.7%	16.1%	p < 0.001	11.1%
Any of above psychiatric disorders	16.8%	40.4%	p < 0.001	39.8%	56.3%	p < 0.001	55.2%
DSM IV psychiatric disorders assessed by MINI interview at baseline
	n = 122,142	n = 226		n = 7,135	n = 108
GAD	4.3%	12.9%	p < 0.001	19.5%	33.7%	p < 0.001	18.2%
Dysthymia	1.2%	3.5%	0.001	5.2%	11.1%	0.006	7.3%
Panic disorder	3.1%	9.3%	p < 0.001	8.2%	12.9%	0.018	8.9%
Social phobia	0.9%	5.6%	p < 0.001	3.9%	7.4%	0.012	3.8%
Agoraphobia	3.2%	7.7%	p < 0.001	6.9%	11.7%	0.032	9.7%
MDD	1.9%	5.5%	p < 0.001	11.2%	26.0%	p < 0.001	11.8%
Any of above DSM-IV disorders	7.7	21.7	p < 0.001	24.7%	38.0%	p = 0.001	27.0%

ns, not significant.